宮園　浩平

  1. Shirakihara T, Horiguchi K, Miyazawa K, Ehata S, Shibata T, Morita I, Miyazono K, Saitoh M. TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. EMBO J. 2011 Jan 11. [Epub ahead of print] (Feb 16) 30(4):783-95
  2. Ehata S, Johansson E, Katayama R, Koike S, Watanabe A, Hoshino Y, Katsuno Y, Komuro A, Koinuma D, Kano MR, Yashiro M, Hirakawa K, Aburatani H, Fujita N, Miyazono K. Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells. Oncogene. 2010 Dec 6. [Epub ahead of print]
  3. Miyazono K, Koinuma D. Arkadia--beyond the TGF-β pathway. J Biochem. 2011; 149(1): 1-3.
  4. Suzuki HI, Miyazono K. Emerging complexity of microRNA generation cascades. J Biochem. 2011; 149(1): 15-25.
  5. Hoshino Y, Katsuno Y, Ehata S, Miyazono K. Autocrine TGF-β protects breast cancer cells from apoptosis through reduction of BH3-only protein, Bim. J Biochem. 2011; 149(1): 55-65.
  6. Mizutani A, Saitoh M, Imamura T, Miyazawa K, Miyazono K. Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling. J Biochem. 2010; 148(6): 733-41.
  7. Johansson E, Komuro A, Iwata C, Hagiwara A, Fuse Y, Watanabe A, Morishita Y, Aburatani H, Funa K, Kano MR, Miyazono K. Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-β-disrupted diffuse-type gastric carcinoma. Cancer Sci. 2010; 101(11): 2398-403.
  8. Sumida H, Noguchi K, Kihara Y, Abe M, Yanagida K, Hamano F, Sato S, Tamaki K, Morishita Y, Kano MR, Iwata C, Miyazono K, Sakimura K, Shimizu T, Ishii S. LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis. Blood. 2010; 116(23): 5060-70.
  9. Kamiya Y, Miyazono K, Miyazawa K. Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction. J Biol Chem. 2010; 285(40): 30804-13.
  10. Nagata M, Nagata S, Yuki K, Isogaya K, Saitoh M, Miyazono K, Miyazawa K. Identification of a phosphorylation site in c-Ski as serine 515. J Biochem. 2010; 148(4): 423-7.
  11. Suzuki HI, Miyazono K. Dynamics of microRNA biogenesis: crosstalk between p53 network and microRNA processing pathway. J Mol Med. 2010; 88(11): 1085-94.

原　英二

  1. Fukuyo Y, Takahashi A, Hara E, Horikoshi N, Pandita TK, Nakajima T. E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability. Int. J. Oral Sci. 2011; 3: 200-208.
  2. Kitajima S, Miki T, Takegami Y, Kido Y, Noda M., Hara E, Shamma A, Takahashi C. Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling. Oncogene 2011; 30: 737-750.

秋山　徹

  1. Funato K, Akiyama T. The tyrosine phosphatase PTPRD suppresses colon cancer cell migration in coordination with CD44. Exp. Therapeutic Medicine In press.
  2. Kawasaki Y, Jigami T, Furukawa S, Sagara M, Echizen K, Shibata Y, Sato R, Akiyama T. The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis. J. Biol. Chem. 2010; 285: 1199-1207.
  3. Taniue K, Nishida A, Hamada F, Sugie A, Oda T, Ui-Tei K, Tabata T, Akiyama T. Sunspot, a link between Wingless signaling and endoreplication in Drosophila. Development 2010; 137: 1755-64.
  4. Nakamura T, Hayashi T, Mimori-Kiyosue Y, Sakaue F, Matsuura K, Iemura S, Natsume T, Akiyama T. The PX-RICS/14-3-3ζ/θ complex couples N-cadherin/b-catenin with Dynein/Dynactin to mediate its export from the endoplasmic reticulum. J. Biol. Chem. 2010; 285: 16145-54.
  5. Roy BC, Kohno T, Iwakawa R, Moriguchi T, Kiyono T, Morishita K, Sanchez-Cespedes M, Akiyama T, Yokota J. Involvement of LKB1 in Epithelial-Mesenchymal Transition (EMT) of Human Lung Cancer Cells. Lung Cancer 2010; 70: 136-45.
  6. Hasegarwa Y, Iizuka-Kogo A, Akiyama T, Senda T. High expression of Pitx-1 in the ICAT-deficient metanephros leads to developmental arrest. Acta. Histochem. Cytochem. 2010; 43: 51-59.

高倉　伸幸

  1. Shioyama W, Nakaoka Y, Higuchi K, Minami T, Taniyama Y, Nishida K, Kidoya H, Sonobe T, Naito H, Arita Y, Hashimoto T, Kuroda T, Fujio Y, Shirai M, Takakura N, Morishita R, Yamauchi-Takihara K, Kodama T, Hirano T, Mochizuki N, Komuro I. Docking Protein Gab1 Is an Essential Component of Postnatal Angiogenesis After Ischemia via HGF/c-Met Signaling. Circ Res. 2011; Feb 3. [Epub ahead of print]
  2. Kumasawa K, Ikawa M, Kidoya H, Hasuwa H, Saito-Fujita T, Morioka Y, Takakura N, Kimura T, Okabe M. Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model. Proc Natl Acad Sci U S A. 2011; 108: 1451-5.
  3. Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, Takakura N. PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives　tumorigenic and metastatic properties. Cancer Res. 2010; 70: 1215-24.
  4. Kidoya H, Naito H, Takakura N. Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia. Blood 2010; 115: 3166-74.
  5. Murakami A, Takasugi H, Ohnuma S, Koide Y, Sakurai A, Takeda S, Hasegawa T, Sasamori J, Konno T, Hayashi K, Watanabe Y, Mori K, Sato Y, Takahashi A, Mochizuki N, Takakura N. Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol Pharmacol. 2010; 77: 704-13.
  6. Nagahama Y, Ueno M, Haraguchi N, Mori M, Takakura N. PSF3 marks malignant colon cancer and has a role in cancer cell proliferation. Biochem Biophys Res Commun. 2010; 392: 150-4.
  7. Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S. A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Cell Metab. 2010; 12: 483-95.
  8. Nakahara I, Miyamoto M, Shibata T, Akashi-Tanaka S, Kinoshita T, Mogushi K, Oda K, Ueno M, Takakura N, Mizushima H, Tanaka H, Ohta T. Up-regulation of PSF1 promotes the growth of breast cancer cells. Genes Cells 2010; 15: 1015-24.
  9. del Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker JS, Larrivee B, Breant C, Duarte A, Takakura N, Fukamizu A, Penninger J, Eichmann A. Identification and functional analysis of endothelial tip cell-enriched genes. Blood 2010; 116: 4025-33.

佐藤　靖史

  1. Saito D, Maeshima Y, Nasu T, Yamasaki H, Tanabe K, Sugiyama H, Sonoda H, Sato Y, Makino H. Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis. Am. J. Phys - Renal Physiol. 2011 Jan 12. [Epub ahead of print]
  2. Sato Y. Is Vasohibin-1 for more than angiogenesis inhibition? J. Biochem. 2011; 149(3):229-30 [Epub ahead of print]
  3. Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, Niikura H, Sasano H, Yaegashi N, Sato Y. Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas. Cancer Sci. 2010 [Epub ahead of print].
  4. Bai X, Margariti A, Hu Y, Sato Y, Zeng L, Ivetic A, Habi O, Mason JC, Wang X, Xu Q. PKCδ-deficiency accelerates neointimal lesion of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation. Arterioscler. Thromb. Vasc. Biol. 2010; 30: 2467-74.
  5. Suzuki Y, Kobayashi M, Miyashita H, Ohta H, Sonoda H, Sato Y. Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion. J. Cell Sci. 2010; 123: 3094-4101.
  6. Zhou SY, Xie ZI, Xiao O, Yang XR, Heng BC, Sato Y. Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1. Mol. Vision 2010; 16: 1389-98.
  7. Yoshida T, Sato Y, Morita I, Abe M. Pigpen, a nuclear coiled body component protein is involved in angiogenesis. Cancer Sci. 2010; 101: 1170-76.
  8. Tamaki K, Sasano H, Maruo Y, Takahashi Y, Miyashita M, Moriya T, Sato Y, Hirakawa H, Tamaki N, Watanabe M, Ishida T, Ohuchi N. Vasohibin-1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast. Cancer Sci. 2010; 101: 1051-58.

Heissig, Beate

  1. Aoki N, Yokoyama R, Asai N, Ohki M, Ohki Y, Kusubata K, Heissig B, Hattori K, Nakagawa Y, Matsuda T. Adipocyte-Derived Microvesicles Are Associated with Multiple Angiogenic Factors and Induce Angiogenesis in Vivo and in Vitro.  Endocrinology 2010; 151: 2567-76.

藤田　直也

  1. Nakazawa Y, Arai H, Fujita N. The novel metastasis promoter Merm1/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis. Cancer Res. 2011; 71: 1146-55.
  2. Morishita D, Takami M, Yoshikawa S, Katayama R, Sato S, Kukimoto-Niino M, Umehara T, Shirouzu M, Sekimizu K, Yokoyama S, Fujita N. Cell-permeable carboxy-terminal p27Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase. J. Biol. Chem. 2011; 286: 2681-88.
  3. Konishi S, Yasuchika K, Ishii T, Fukumitsu K, Kamo N, Fujita N, Ikai I, Uemoto S. A transmembrane glycoprotein, gp38, is a novel marker for immature hepatic progenitor cells in fetal mouse livers. In Vitro Cell. Dev. Biol. Anim. 2011; 47: 45-53.
  4. Misawa A, Katayama R, Koike S, Tomida A, Watanabe T, Fujita N. AP-1-dependent miR-21 expression contributes to chemoresistance in cancer stem cell-like SP cells. Oncol. Res. 2010; 19: 23-33.
  5. Nakamura A, Naito M, Arai H, Fujita N. Mitotic phosphorylation of Aki1 at Ser208 by cyclin B1-Cdk1 complex. Biochem. Biophys. Res. Commun. 2010; 393: 872-76.
  6. Péterfy M, Harris TE, Fujita N, Reue K. Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes. J. Biol. Chem. 2010; 285: 3857-64.
  7. Katayama R, Ishioka T, Takada S, Takada R, Fujita N, Tsuruo T, Naito M. Modulation of Wnt signaling by the nuclear localization of cellular FLIP-L. J. Cell Sci. 2010; 123: 23-28.

近藤　科江

  1. Kizaka-Kondoh S*, Kuchimaru T, Kadonosono T. HIF-1-active cells as a target for cancer therapy. J. Pharmacol. Sci., in press.
  2. Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka S, Kizaka-Kondoh S, Hiraoka M, Saji H. PET Imaging of Hypoxia-Inducible Factor-1-Active Tumor Cells with Pretargeted Oxygen-Dependent Degradable Streptavidin and a Novel (18)F-Labeled Biotin Derivative. Mol. Imaging Biol., 2010 Sep 14. [Epub ahead of print]
  3. Kuchimaru T, Kadonosono T, Tanaka S, Ushiki T, Hiraoka M, Kizaka-Kondoh S*. In Vivo Imaging of HIF-Active Tumors by an Oxygen-Dependent Degradation Protein Probe with an Interchangeable Labeling System. PLoS One 2010; 5(12): e15736.
  4. Fujita Y, Ihara M, Ushiki T, Hirai H, Kizaka-Kondoh S, Hiraoka M, Ito H, Takahashi R. Early Protective Effect of Bone Marrow Mononuclear Cells Against Ischemic White Matter Damage Through Augmentation of Cerebral Blood Flow. Stroke  2010; 41(12): 2938-43.
  5. Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka-Kondoh S, Aoki M, Taketo MM. Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Proc. Natl. Acad. Sci. U. S. A. 2010; 107(29): 13063-68.
  6. Ushiki T, Kizaka-Kondoh S*, Ashihara E, Tanaka S, Masuko M, Hirai H, Kimura S, Aizawa Y, Maekawa T, Hiraoka M. Noninvasive tracking of donor cell homing by near-infrared fluorescence imaging shortly after bone marrow transplantation. PLoS One 2010; 5(6):e11114.
  7. Ueda M, Kudo T, Kuge Y, Mukai T, Tanaka S, Konishi H, Miyano A, Ono M, Kizaka-Kondoh S, Hiraoka M, Saji H. Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha. Eur. J.Nucl. Med. Mol. Imaging 2010; 37(8): 1566-74..
  8. Kimura M, Murakami T, Kizaka-Kondoh S, Itoh M, Yamamoto K, Hojo Y, Takano M, Kario K, Shimada K, Kobayashi E. Functional molecular imaging of integrin-linked kinase-Akt/PKB-mediated signaling and associated role of beta-parvin. J.Cell.Sci. 2010; 123: 747-55.
  9. Tanaka T, Wakamatsu T, Daijo H, Oda S, Kai S, Adachi T, Kizaka-Kondoh S, Fukuda K, Hirota K. Persisting mild hypothermia suppresses hypoxia-inducible factor 1{alpha} protein synthesis and HIF-1-mediated gene expression. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2010; 298(3): R661-71 .

矢野　聖二

  1. Yano S, Wang W, Li Q, Yamada T, Takeuchi S, Matsumoto K, Nishioka Y, Sone S. HGF-MET in resistance to EGFR tyrosine kinase inhibitors in lung cancer. Hepatocyte growth factor and its receptor signaling and the therapeutic implications. Curr. Signal .Transd. T. (in press).
  2. Donev IS, Wang W, Yamada T, Li Q, Takeuchi S, Matsumoto K, Yamori T, Nishioka Y, Sone S, Yano S. Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer. Clin. Cancer. Res. 2011 Jan 10. [Epub ahead of print]
  3. Tanaka S, Nakada M, Hayashi Y, Nakada S, Kitamura-Sawada S, Furuyama N, Suzuki T, Kamide T, Hayashi Y, Yano S, Hamada JI. Epithelioid glioblastoma changed to typical glioblastoma -the methylation status of MGMT promoter and 5-ALA fluorescence. Brain Tumor Pathol. 2011 Feb;28(1):59-64. Epub 2010 Dec 25.
  4. Tanaka H, Kimura T, Kudoh S, Mitsuoka S, Watanabe T, Suzumura T, Tachibana K, Noguchi M, Yano S, Hirata K. Reaction of plasma hepatocyte growth factor level in lung cancer patients treated with EGFR-TKIs. Int. J. Cancer 2010 Dec 2. [Epub ahead of print]
  5. Yano S, Li Q, Wang W, Yamada T, Takeuchi S, Nakataki E, Ogino H, Goto H, Nishioka Y, Sone S. Antiangiogenic therapies for malignant pleural mesothelioma. Front Biosci. 2011;16 :740-8.
  6. Shiirevnyamba A, Takahashi T, Shan H, Ogawa H, Yano S, Kanayama H, Izumi K, Uehara H. Enhancement of osteoclastogenic activity in osteolytic prostate cancer cells by physical contact with osteoblasts. Br. J. Cancer 2011;104: 505-13.
  7. Izumi K, Narimoto K, Sugimoto K, Kobori Y, Maeda Y, Mizokami A, Koh E, Yamada T, Yano S, Namiki M. The Role of Percutaneous Needle Biopsy in Differentiation of Renal Tumors. Jpn. J. Clin. Oncol. 2010; 40:1081-6.
  8. Yamada T, Ohtsubo K, Izumi K, Takeuchi S, Mouri H, Yamashita K,Yasumoto K, Ghenev P, Kitagawa S, Yano S. Metastatic renal cell carcinoma complicated with diffuse alveolar hemorrhage: a rare adverse effect of sunitinib. Int. J. Clin. Oncol. 2010; 15:638-41.
  9. Kanematsu T, Hanibuchi M, Tomimoto H, Sakiyakma S, Kenzaki K, Kondo K, Bando H, Haku T, Yoneda K, Hirose T, Toyoda Y, Goto H, Sakaguchi S, Kinoshita K, Azuma M, Kakiuchi S, Kishi J, Azuma M, Tada H, Sumitomo M, Nishioka Y, Yano S, Sone S. Epidemiological and clinical features of lung cancer patients from 1999 to 2009 in Tokushima Prefecture of Japan. J. Med. Invest. 2010; 57: 326-33.
  10. Sakaguchi S, Goto H, Hanibuchi M, Otsuka S, Ogino H, Kakiuchi S, Uehara H, Yano S, Nishioka Y, Sone S. Gender difference in bone metastasis of human small cell lung cancer, SBC-5 cells in natural killer-cell depleted severe combined immunodeficient mice. Clin. Exp. Metastasis 2010; 27:351-9.
  11. Yamada T, Matsumoto K, Wang W, Li Q, Nishioka Y, Sone S, Yano S. Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer. Clin. Cancer Res. 2010; 16:174-83.
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